The Implications of Calorie Restriction on Longevity and Health Span
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چکیده
Calorie Restriction (CR) is a defined intervention tool currently being studied as an effort to achieve numerous health benefits and increase longevity. Currently, there is a large body of research that indicates a multitude of health benefits and positive associations; however, there is also a plethora of opposing research. Through investigation of epigenetics, the efficacy of calorie restriction is being examined to provide insight into its potential benefits. The alterations to metabolic pathways may also reveal a reduction in inflammation and oxidative stress, markers of aging-related disease. In addition, both animal and human studies take a closer look at the effects of calorie restriction on preservation of mitochondria and reduction of chronic disease. The idea of amelioration of these symptoms is extremely attractive; a body of literature suggests the possibility of mimicking the potential effects without calorie restriction at all. Regardless, as this new topic emerges, researchers’ conclusions come closer and closer to making clinical recommendations.
منابع مشابه
Aging, adiposity, and calorie restriction.
CONTEXT Excessive calorie intake and subsequent obesity increases the risk of developing chronic disease and decreases life expectancy. In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span. OBJECTIVE To evaluate the physiological and clinical implications of calorie restriction with adequate nutrient...
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